Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs / Mohd Syahir Anwar Hamzah …[et al.]

Anwar Hamzah, Mohd Syahir and Ng, Celine and Abdul Sukor, Jumadi and Mohd Ali, Kamarul Syazwan and Mat Nayan, Nadirul Hasraf (2021) Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs / Mohd Syahir Anwar Hamzah …[et al.]. Journal of Mechanical Engineering (JMechE), 8 (1). pp. 39-51. ISSN (eISSN): 2550-164X

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Abstract

Porous nanofiber electrospun of polyvinylidene fluoride (PVDF)/pectin was successfully developed using electrospinning method containing benzalkonium chloride (BAC) as a drug model for the controlled drug delivery system assessment. The electrospun was tested for its mechanical, morphological, and wettability properties. Scanning electron microscope (SEM) micrograph demonstrated that the smooth surfaces of nanofibers morphology had achieved up to 2 wt% pectin inclusion with optimum fiber diameter, 143 ± 1.4 nm. The optimized scaffold PVDF/Pectin showed that the reduction of mechanical integrity and optimum value of tensile strength, modulus strength, and elongation at break were 5.98 ± 0.17 MPa, 16.82 ± 0.10 MPa, and 79.3 ± 1.3% MPa. Water contact angle analysis and degree of swelling suggested that inclusion of pectin had enhanced the wettability properties of hydrophobic PVDF electrospun with highest swelling capacity achieved of 78.9 ± 1.7%. The in vitro drug release tests using BAC, which was released from the hybrid electrospun nanofibers, achieved prolonged release profile due to elimination of the uncontrollable initial burst release.

Metadata

Item Type: Article
Creators:
Creators
Email
Anwar Hamzah, Mohd Syahir
UNSPECIFIED
Ng, Celine
UNSPECIFIED
Abdul Sukor, Jumadi
UNSPECIFIED
Mohd Ali, Kamarul Syazwan
UNSPECIFIED
Mat Nayan, Nadirul Hasraf
nadirul@uthm.edu.my
Subjects: Q Science > QD Chemistry > Physical and theoretical chemistry
Q Science > QD Chemistry > Analytical chemistry
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Mechanical Engineering
Journal or Publication Title: Journal of Mechanical Engineering (JMechE)
UiTM Journal Collections: UiTM Journal > Journal of Mechanical Engineering (JMechE)
ISSN: (eISSN): 2550-164X
Volume: 8
Number: 1
Page Range: pp. 39-51
Official URL: https://jmeche.uitm.edu.my/
Item ID: 47619
Uncontrolled Keywords: Electrospinning, drug delivery, polyvinylidene fluoride
URI: https://ir.uitm.edu.my/id/eprint/47619

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47619

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