Synthesis of four-arms star-shaped PCL-b-PEG as a potential amphiphilic hydrogel / Wafiuddin Ismail ... [et al.]

Ismail, Wafiuddin and Wan Abdul Khodir, Wan Khartini and Abd Hamid, Shafida Abd Hamid and Daik, Rusli (2021) Synthesis of four-arms star-shaped PCL-b-PEG as a potential amphiphilic hydrogel / Wafiuddin Ismail ... [et al.]. Scientific Research Journal, 18 (1). pp. 101-117. ISSN 2289-649X

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Abstract

Hydrogel formulations have drawbacks in delivering hydrophobic drugs which can aJect its effciency. Introducing amphiphilic system into hydrogel can overcome this limitation and increase hydrogel effectiveness as a drug cargo. In this study, four arms star-shaped block copolymers with polyethylene glycol (PEG) as hydrophilic block and polycaprolactone (PCL) as hydrophobic block were synthesized via a combination of ring- opening polymerisation (ROP) and Steglich esterification. The structures were confirmed by 1 H-NMR and FTIR analysis. The polydispersity index (PDI) indices from gas permeation chromatography (GPC) were 1.3 to 1.6, suggesting controlled polymerisation reaction occurred. Average molecular weight analysis, Mn based on 1 H-NMR are close to the theoretical value. However, there is a slight difference of Mn between GPC and proton analysis due to the ability of GPC determining Mn for the star-shaped polymer. Both star-shaped polymers possess high thermal stability (>350 °C) based on thermal decomposition study using TGA analysis. The presence of PEG had increased the hydrophilicity and solubility of the PCL in the hydrogel since an opaque homogeneous formulation form when using the amphiphilic star-shaped polymer. The pH (7.25 ± 0.03) and viscosity (9330 cP) of the formulation are set within the compatibility and suitable for human skin and topical application.

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Item Type: Article
Creators:
Creators
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Ismail, Wafiuddin
UNSPECIFIED
Wan Abdul Khodir, Wan Khartini
UNSPECIFIED
Abd Hamid, Shafida Abd Hamid
UNSPECIFIED
Daik, Rusli
UNSPECIFIED
Subjects: Q Science > QD Chemistry > Physical and theoretical chemistry > Chemical elements
Q Science > QD Chemistry > Physical and theoretical chemistry > Theory of solution
T Technology > TP Chemical technology > Chemicals
Divisions: Universiti Teknologi MARA, Shah Alam > Research Management Centre (RMC)
Journal or Publication Title: Scientific Research Journal
UiTM Journal Collections: UiTM Journal > Scientific Research Journal (SRJ)
ISSN: 2289-649X
Volume: 18
Number: 1
Page Range: pp. 101-117
Official URL: http://srj.uitm.edu.my/
Item ID: 44987
Uncontrolled Keywords: PCL-PEG star-shaped polymer; ring-opening polymerisation; hydrogel formulation
URI: https://ir.uitm.edu.my/id/eprint/44987

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44987

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