Medical Management of Open-Angle Glaucoma: Focus on Mechanisms of Action and Adverse Drug Reactions / Amy Suzana Abu Bakar ...[et al.]

Abu Bakar, Amy Suzana and Razali, Norhafiza and Hassan, Mohammad Daniel Shafiq and Agarwal, Renu (2021) Medical Management of Open-Angle Glaucoma: Focus on Mechanisms of Action and Adverse Drug Reactions / Amy Suzana Abu Bakar ...[et al.]. Journal of Clinical and Health Sciences, 6 (1). pp. 4-17. ISSN 0127 – 984X

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Abstract

Glaucoma is an optic neuropathy characterised by optic nerve degeneration associated with visual field defects. It remains the world’s number one cause of irreversible blindness and patients usually present at late stage of the disease since it is generally asymptomatic until severe. The disease is subdivided into primary and secondary with primary open-angle glaucoma (POAG) being the most common type. At present, lowering the intraocular pressure (IOP) remains the only proven efficient approach in delaying the onset or preventing the progression of the disease. Medical treatment with topical antiglaucoma agents is the treatment of choice in open angle glaucoma. The use of antiglaucoma drugs aims to reduce IOP by enhancing aqueous humour (AH) outflow, reducing AH production, or both. The choice to use any available treatment option should be carefully considered in an attempt to maximise benefits and reducing the risk of developing adverse drug reactions. This review highlights the six classes of ocular hypotensive agents currently in use for POAG treatment including prostaglandin analogues; -adrenergic receptor blockers; -2 adrenergic receptor stimulants; carbonic anhydrase inhibitors; muscarinic receptor stimulants; rho kinase inhibitors with regards to their mechanism/s of action and potential adverse drug reactions, and antiglaucoma fixed drug combinations.

Metadata

Item Type: Article
Creators:
Creators
Email
Abu Bakar, Amy Suzana
UNSPECIFIED
Razali, Norhafiza
UNSPECIFIED
Hassan, Mohammad Daniel Shafiq
UNSPECIFIED
Agarwal, Renu
UNSPECIFIED
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > Public health. Hygiene. Preventive Medicine
R Medicine > RE Ophthalmology
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Journal or Publication Title: Journal of Clinical and Health Sciences
UiTM Journal Collections: UiTM Journal > Journal of Clinical and Health Sciences (JCHS)
ISSN: 0127 – 984X
Volume: 6
Number: 1
Page Range: pp. 4-17
Official URL: https://jchs-medicine.uitm.edu.my/index.php
Item ID: 44211
Uncontrolled Keywords: antiglaucoma, intraocular pressure, trabecular meshwork, adverse effects, aqueous humour, primary open-angle glaucoma, ocular hypertension
URI: https://ir.uitm.edu.my/id/eprint/44211

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44211

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