Changes in the structure and mechanical properties of bone tissues obtained from experimental animal models of lifestyle-related diseases / Ei Yamamoto and Yuki Kawamura

Ei, Yamamoto and Yuki, Kawamura (2018) Changes in the structure and mechanical properties of bone tissues obtained from experimental animal models of lifestyle-related diseases / Ei Yamamoto and Yuki Kawamura. Journal of Mechanical Engineering (JMechE), SI 5 (5). pp. 226-234. ISSN 18235514

Abstract

Lifestyle-related diseases such as diabetes and hypertension are a major public health problem in the world. It is well known that these diseases directly affect the characteristics of cardiovascular tissues. However, there has been little information on the effects of diabetes or hypertension on the biomechanical properties of musculoskeletal tissues. We hypothesized that diabetes or hypertension is related to impaired material and structural properties of bones. To examine this hypothesis, mechanical loading tests were conducted to determine the stress-strain relations of cortical bone specimens obtained from experimental animal models of diabetes or hypertension. Zucker diabetic fatty rats (Diabetic group), stroke-prone spontaneously hypertensive rats (Hypertensive group), and normal Wistar rats (Control group) were used for the experiments. Cortical bone specimens were obtained from the femora of the rats, and compressive forces were applied to the specimens until failure using a conventional material tester. In addition, the trabecular structure of the femoral neck was observed using an X-ray micro-computed tomography. Bone compressive strength in the diabetic group was significantly lower than that of the control group. Trabecular bone in the hypertensive group has a higher porosity than that in the control group. These findings support the concept that bone metabolism may be impaired in diabetic or hypertensive subjects.

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Ei, Yamamoto
ei@waka.kindai.ac.jp
Yuki, Kawamura
UNSPECIFIED
Subjects: Q Science > QA Mathematics > Analytic mechanics
T Technology > TJ Mechanical engineering and machinery
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Mechanical Engineering
Journal or Publication Title: Journal of Mechanical Engineering (JMechE)
UiTM Journal Collections: UiTM Journal > Journal of Mechanical Engineering (JMechE)
ISSN: 18235514
Volume: SI 5
Number: 5
Page Range: pp. 226-234
Keywords: Biomechanics, Bone, Diabetes, Hypertension, Mechanical Properties.
Date: 2018
URI: https://ir.uitm.edu.my/id/eprint/40664
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