Study on the co-crystal formation of ibuprofen and oxalic acid via evaporation method / Muhamad Fitri Othman and Nor Adila Abdul Rahman

Othman, Muhamad Fitri and Abdul Rahman, Nor Adila (2018) Study on the co-crystal formation of ibuprofen and oxalic acid via evaporation method / Muhamad Fitri Othman and Nor Adila Abdul Rahman. Malaysian Journal of Chemical Engineering and Technology (MJCET), 1. pp. 22-27. ISSN 2682-8588

Abstract

Co-crystallisation is the process where the combination of two compound which are active
pharmaceutical ingredient (API) compound with the co-former by the non-covalent interaction.
This process is believed can enhance the physicochemical properties of the API including solubility,
stability, dissolution rate, melting point and its bioavailability. Due to this, the research for the cocrystallisation of the Ibuprofen and oxalic acid as it co-former had conducted by using the slow
evaporation method. The analysis and characterisation of this co-crystal was conducted by using
the optical microscope, Fourier transform infrared spectroscopy (FTIR), differential scanning
calorimeter (DSC), and X-ray diffraction (XRD). The observation using optical microscope had
shown that the co-crystal grew in the dendrite and rod shape. From the characterisation of the cocrystals in FTIR, it shows the shift of peak which revealed the formation of the co-crystal structure.
Then, the DSC showed that the melting point of co-crystals were higher than the pure ibuprofen.
This showed that the co-crystal had higher thermodynamic stability than the pure API. The
characterisation of the ibuprofen-oxalic acid (IBP: OA) co-crystal by using the XRD had proved
that there is new crystallographic structure formed by comparing it with the pure compound. These
results showed the co-crystals had formed.

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Othman, Muhamad Fitri
UNSPECIFIED
Abdul Rahman, Nor Adila
UNSPECIFIED
Subjects: Q Science > QC Physics > Heat
T Technology > TP Chemical technology > Heating, drying, cooling, evaporating
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Chemical Engineering
Journal or Publication Title: Malaysian Journal of Chemical Engineering and Technology (MJCET)
UiTM Journal Collections: UiTM Journal > Malaysian Journal of Chemical Engineering and Technology (MJCET)
ISSN: 2682-8588
Volume: 1
Page Range: pp. 22-27
Keywords: Co-crystallisation, Ibuprofen, Oxalic acid, Solubility, Stability
Date: 2018
URI: https://ir.uitm.edu.my/id/eprint/37485
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