Synthesis, spectral characterisation and antimicrobial properties of Cu(II) and Fe(II) complexes with xanthone / Rabuyah Ni, Mohammad Isa Mohamadin and Vivien Yi Mian Jong

Ni, Rabuyah and Mohamadin, Mohammad Isa and Mian Jong, Vivien Yi (2017) Synthesis, spectral characterisation and antimicrobial properties of Cu(II) and Fe(II) complexes with xanthone / Rabuyah Ni, Mohammad Isa Mohamadin and Vivien Yi Mian Jong. Scientific Research Journal, 14 (1). pp. 1-14. ISSN 2289-649X

Download

[thumbnail of 34779.pdf] Text
34779.pdf

Download (5MB)
Official URL: https://srj.uitm.edu.my/

Abstract

The new complexes [CuL2(H2O)2] and [FeL2(CH3O)2] in which L = β-mangostin were synthesised and characterised. The structure of the ligand, β-mangostin was confirmed using NMR and the purity of ligand was determined using HPLC. Both Cu(II) and Fe(II) complexes were prepared by reaction between the ligand and the acetate of the metals in one-step reaction. The synthesised compounds have been characterised using UV-Visible, FTIR and CHNS analyser. Ligand and metal complexes were tested against bacteria to assess on their antimicrobial properties using Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs) method. The elemental analysis and spectra data suggested octahedral geometry for both Cu(II) and Fe(II) complexes. The IR spectroscopy revealed that the chelation of Cu2+ and Fe2+ ion occurred with hydroxyl and carbonyl group at C9 and C1 respectively of β-mangostin. Both Cu(II) and Fe(II) complexes showed stronger inhibition against Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and Salmonella pneumonia at concentration 900 mg/mL and Escherichia coli at 450 mg/mL compared to the ligand itself.

Metadata

Item Type: Article
Creators:
Creators
Email
Ni, Rabuyah
UNSPECIFIED
Mohamadin, Mohammad Isa
UNSPECIFIED
Mian Jong, Vivien Yi
UNSPECIFIED
Subjects: Q Science > QR Microbiology > Microbial ecology
Divisions: Universiti Teknologi MARA, Shah Alam > Research Management Centre (RMC)
Journal or Publication Title: Scientific Research Journal
UiTM Journal Collections: UiTM Journal > Scientific Research Journal (SRJ)
ISSN: 2289-649X
Volume: 14
Number: 1
Page Range: pp. 1-14
Official URL: https://srj.uitm.edu.my/
Item ID: 34779
Uncontrolled Keywords: iron(II) complex, antimicrobial, xanthones
URI: https://ir.uitm.edu.my/id/eprint/34779

ID Number

34779

Indexing


View in Google Scholar

Edit Item
Edit Item