Elyagoby, Assad Ali Faraj
(2014)
Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby.
In:
The Doctoral Research Abstracts.
IPSis Biannual Publication, 6
(6).
Institute of Graduate Studies, UiTM, Shah Alam.
Abstract
Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-fluorouracil. The solid coating powder was constituted of ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to spheroids was varied between 2:3 and 3:2. Delayed 5-fluorouracil release was obtained when the weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3, and weight ratio of solid coating powder to spheroids was kept at 3:2 with particle size of ethylcellulose reduced to 22 μm.
Item Details
| Item Type: | Book Section |
|---|---|
| Creators: | Creators Email / ID Num. Elyagoby, Assad Ali Faraj UNSPECIFIED |
| Subjects: | L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia |
| Divisions: | Universiti Teknologi MARA, Shah Alam > Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS) |
| Series Name: | IPSis Biannual Publication |
| Volume: | 6 |
| Number: | 6 |
| Keywords: | Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; Colon-specific delivery |
| Date: | 2014 |
| URI: | https://ir.uitm.edu.my/id/eprint/19620 |
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