Abstract
Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP).
Metadata
| Item Type: | Book Section |
|---|---|
| Creators: | Creators Email / ID Num. Ibrahim, Hisham Saleh UNSPECIFIED |
| Subjects: | L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia |
| Divisions: | Universiti Teknologi MARA, Shah Alam > Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS) |
| Series Name: | IPSis Biannual Publication |
| Volume: | 6 |
| Number: | 6 |
| Keywords: | Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; Endothelial activation |
| Date: | 2014 |
| URI: | https://ir.uitm.edu.my/id/eprint/19615 |
- Edit Item
Download
ABS_HISHAM SALEH IBRAHIM TDRA VOL 6 IGS_14.pdf
Download (416kB) | Preview
ID Number
19615
Indexing
