Heterogeneous response to semaglutide in long-standing T2DM and obesity: a case report

Shariffudin, Nur Asilah and M, Aimi Fadilah and Ew, Nur Aini and A, Mohd Hazriq and B, Nur Haziqah and Ms, Fatimah Zaherah and Ag, Rohana (2026) Heterogeneous response to semaglutide in long-standing T2DM and obesity: a case report. Journal of Clinical and Health Sciences (JCHS), 11 (SUPP2). pp. 34-35. ISSN 0127-984X

Official URL: https://jchs-medicine.uitm.edu.my

Abstract

Obesity is a chronic, relapsing disease and is a major contributor to type 2 diabetes mellitus (T2DM) and cardiovascular morbidity. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated significant benefits in weight reduction and glycemic control. However, real-world data revealed marked inter-individual variability in treatment response, particularly in patients with severe obesity, long-standing T2DM, and advanced insulin resistance.

Item Details

Item Type:	Article
Creators:	Creators Email / ID Num. Shariffudin, Nur Asilah nurasilahshariffudin@gmail.com M, Aimi Fadilah UNSPECIFIED Ew, Nur Aini UNSPECIFIED A, Mohd Hazriq UNSPECIFIED B, Nur Haziqah UNSPECIFIED Ms, Fatimah Zaherah UNSPECIFIED Ag, Rohana UNSPECIFIED
Subjects:	R Medicine > RC Internal Medicine > Specialties of internal medicine > Metabolic diseases > Obesity R Medicine > RC Internal Medicine > Diabetes Mellitus
Divisions:	Universiti Teknologi MARA, Selangor > Sungai Buloh Campus > Faculty of Medicine
Journal or Publication Title:	Journal of Clinical and Health Sciences (JCHS)
ISSN:	0127-984X
Event Title:	2nd National Obesity Scientific Conference
Event Dates:	11-12 April 2026
Volume:	11
Number:	SUPP2
Page Range:	pp. 34-35
Keywords:	Semaglutide, Type 2 diabetes mellitus, T2DM, Obesity, Case report, Metabolic response
Date:	September 2026
URI:	https://ir.uitm.edu.my/id/eprint/147453

: Edit Item

Downloads & Files

Text
147453.pdf

Download (227kB)

Indexing & Metrics