Systematic review and bibliometric analysis of genetic factors influencing hematologic traits: implications for blood donor screening

Genetic variation plays a role in blood disorders involving iron metabolism, hemoglobin regulation, and thrombophilia, all of which may influence blood donor health and the quality of donated blood. Understanding these genetic determinants across diverse populations is important for improving donor selection, supporting safer blood donation practices, and strengthening transfusion outcomes. This systematic review evaluates reported genetic variants associated with these disorders and their potential application in blood donor screening.