The protective effect of Polygonum minus ethanolic fraction against cisplatin-induced hepatotoxicity via MAPK signalling transduction pathways

Zulfikri, Nurul Illiya Zafirah (2026) The protective effect of Polygonum minus ethanolic fraction against cisplatin-induced hepatotoxicity via MAPK signalling transduction pathways. Masters thesis, Universiti Teknologi MARA (UiTM).

Abstract

Cisplatin (CP) is an effective chemotherapeutic agent but its clinical use is limited by severe hepatotoxicity, prompting the exploration of natural antioxidant sources to counter these adverse effects. This study investigated the protective effect of P. minus ethanolic fraction (PMEF) against CP-induced hepatotoxicity via MAPK signalling pathways. PMEF samples were extracted from P. minus leaves by maceration and subjected to polarity-based fractionation using hexane, ethyl acetate, and 70% ethanol+water. Phytochemical screening for PMEF was evaluated using Shinoda test.

Metadata

Item Type:	Thesis (Masters)
Creators:	Creators Email / ID Num. Zulfikri, Nurul Illiya Zafirah 2022734629
Contributors:	Contribution Name Email / ID Num. Thesis advisor Adib Ridzuan, Nurul Raudzah UNSPECIFIED
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Universiti Teknologi MARA, Shah Alam > Faculty of Medicine
Programme:	Master of Science (Medicine)
Keywords:	Polygonum minus, Cisplatin , Hepatotoxicity
Date:	2026
URI:	https://ir.uitm.edu.my/id/eprint/135515