Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa

Musa, Nafisah (2012) Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa. Masters thesis, Universiti Teknologi MARA.


Conventional melt pelletization and granulation processes produce round and dense,
and irregularly shaped but porous agglomerates respectively. This study aimed to
design centrifugal air-assisted melt agglomeration technology for manufacture of
spherical and yet porous "granulets" for ease of downstream manufacturing and
enhancing drug release. A bladeless agglomerator, which utilized shear-free air stream
to mass the powder mixture of lactose filler, polyethylene glycol binder and poorly
water-soluble tolbutamide drug into "granulets", was developed. The inclination angle
and number of vane, air-impermeable surface area of air guide, processing
temperature, binder content and molecular weight were investigated with reference to
"granulet" size, shape, texture and drug release properties. Unlike fluid-bed melt
agglomeration with vertical processing air flow, the air stream in the present
technology moved centrifugally to roll the processing mass into spherical but porous
"granulets" with a drug release propensity higher than physical powder mixture,
unprocessed drug and dense pellets prepared using high shear mixer. The fast-release
attribute of "granulets" was ascribed to porous matrix formed with a high level of
polyethylene glycol as solubilizer. The agglomeration and drug release outcomes of
centrifugal air-assisted technology are unmet by the existing high shear and fluid-bed
melt agglomeration techniques.


Item Type: Thesis (Masters)
Email / ID Num.
Musa, Nafisah
Subjects: R Medicine > RM Therapeutics. Pharmacology > Drugs and their actions
R Medicine > RS Pharmacy and materia medica
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Programme: Master of Science (Pharmaceutical Technology)
Keywords: Conventional melt pelletization, bladeless agglomerator, granulets
Date: 2012
URI: https://ir.uitm.edu.my/id/eprint/12999
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