FT-IR analysis on the inclusion complex of Β-Cyclodextrin with quercetin, naringenin, 3-Hydroxyflavone and chrysin via different preparation methods / Noor Amilia Khosim, Ainnie Rahayu Abdullah and Marina Mokhtar

Khosim, Noor Amilia and Abdullah, Ainnie Rahayu and Mokhtar, Marina (2015) FT-IR analysis on the inclusion complex of Β-Cyclodextrin with quercetin, naringenin, 3-Hydroxyflavone and chrysin via different preparation methods / Noor Amilia Khosim, Ainnie Rahayu Abdullah and Marina Mokhtar. Esteem Academic Journal, 11 (1). pp. 72-80. ISSN 1675-7939

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Abstract

Flavonoids are used widely in the pharmaceutical industry due to their anti-oxidative and anti-inflammatory properties. However, most of the flavonoids are poorly water-soluble. These experiments were conducted to prepare the inclusion complex of β-Cyclodextrin with selected flavonoids such as Quercetin, Naringenin, 3-Hydroxyflavone and Chrysin. The methods used in complexing the host and guest molecules are modified physical mixture, kneading and freeze drying method by using the molar ratio of 1:1. The
complexations of the flavonoids tested were analyzed by the Fourier Transform Infrared (FT-IR)spectroscopy. Analysis results suggested that the best method to complex β-Cyclodextrin with Quercetin and Chrysin, were via modified
kneading method. Complexation of Naringenin and 3-Hydroxyflavone was best done via modified freeze drying and physical mixture method respectively.

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Item Type: Article
Creators:
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Khosim, Noor Amilia
UNSPECIFIED
Abdullah, Ainnie Rahayu
UNSPECIFIED
Mokhtar, Marina
UNSPECIFIED
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical dosage forms
Divisions: Universiti Teknologi MARA, Pulau Pinang
Journal or Publication Title: Esteem Academic Journal
ISSN: 1675-7939
Volume: 11
Number: 1
Page Range: pp. 72-80
Item ID: 11993
Uncontrolled Keywords: Inclusion comple, β-cyclodextrin, Quercetin, Naringenin, 3-Hydroxyflavone, Chrysin, Fourier Transform Infrared spectroscopy
URI: https://ir.uitm.edu.my/id/eprint/11993

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11993

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