Synthesis and characterization of hybrid alginate/ cellulose as drug delivery system: article

The technology behind drug delivery system has expanded vastly nowadays. By searching the best ingredient in order to treat people, researcher has come up with one of the best materials. The materials here are alginate and cellulose. Alginate that come from green algae and cellulose that is derived from plant. The new things here that will be developed are hybrid or combinations of alginate and cellulose aerogel. Aerogel in the other hand is solid like material consists of 99% of air. In this study, the hybrid alginate/ cellulose aerogel was prepared using the sol-gel method. Sol means solution and gel is when the mixture of solvent which is distilled water, alginate, cellulose, calcium carbonate (CaCO3), paracetamol, and glucono-δ-lactone (GDL) is combined and when it is complete it the mixture turned into gel and that is called sol-gel. Then, these hybrid alginate/ cellulose aerogel were further drying with air drying and supercritical drying of Carbon Dioxide (CO2). Hybrid alginate/ cellulose aerogel was loaded with paracetamol to investigate the drug release characteristics. This hybrid alginate/ cellulose were analyzed using Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), and thermogravimetric analysis (TGA). Release results indicate that the hybrid aerogels loaded with paracetamol with 3wt% alginate+ 1wt% Carboxymethyl Cellulose (CMC) show better drug absorption for drug delivery because the surface area covered with paracetamol is bigger compared to blank hybrid alginate/ cellulose aerogel