Co-crystallization of acetaminophen with phenolic constituents of kacip fatimah (fla vonoids) / Izzati Afiqah Jailani

Co-crystallization is a process of combining two or more chemical compounds in a specific stoichiometric ratio. Previous studies of co-crystallization of acetaminophen with other chemicals have improved its mechanical and physical properties. Labisia pumila contains many phytochemicals and flavonoid is one of the class present in this plant. Co-crystallization of acetaminophen and flavonoids is undertaken to study the interaction feasibility between both compounds, either the interaction causes formation of new compound or the interaction causes changes in the unit cell properties of the compound which may be an important parameter in drug formulation. The co­ crystallization of acetaminophen with flavonoids involves preliminary characterization, co-crystal formation and co-crystal characterization. The results showed that there is no crystal formation between acetaminophen with quercetin and rutin hydrate. Only the combination of acetaminophen:naringenin (1:2 molar ratio) showed good crystals.