5-fluorouracil loaded egg albumin-cyclodextrin nanoparticles for targeted drug delivery in breast cancer treatment / Hanisah Baharin

Breast cancer is the cancer that majorly caused death among women worldwide. There are many studies and development associated with the breast cancer treatment yet, no one of them was fully successful to eradicate the cancer cell. The ineffective chemotherapeutic nowadays is mostly due to the less specific targeting of the anticancer drug to cancer cell and had caused many side effects. However, the study of nanoparticles as more targeted drug deliver is now been concerned. Therefore, we conducted a study on the characteristic of 5-fluorouracil loaded egg albumin-cyclodextrin nanoparticles as targeted delivery in breast cancer treatment. Four samples of nanoparticles had been prepare with optimization of the drug content which is Omg, 2mg, 4mg and 6mg.these nanoparticles undergo three characterizations which were zetasizer, scanning electron microscope and transmission electron microscope. Based on the characterization data, the size of the nanoparticles were within 1 OOnm to 400nm. The increments of the size of nanoparticles were relevant on the amount of drug content. As the amounts of the drug content were increased, the larger the size of the nanoparticles had formed. This study may encourage future study of the specificity and selectivity of nanoparticles to cancer cells.