Formulation and evaluation of fluconazole in emulgel topical application / Mohamad Zulhasmi Hamzah

The aim of the following research was to formulate tluconazole in emulgel form and to evaluate the release of the medicament from it. Emulgel containing 1 % w/w of tluconazole was prepared by addition of a gelling agent; Carbopol 934 to an emulsion using Span 80 as emulsifying agent. The release of tluconazole was determined by Franz diffusion cell using cellulose acetate membrane for a period of 3 hours at 32°C. Fluconazole was analyzed by ultra-violet (UV) Spectrophotometer at 261 nm. The prepared formula of tluconazole emulgel proved to be more efficient than other externally applied topical preparations as lotion, ointment and gel.