Prevalence of ESBL-producing Klebsiella pneumoniae and Escherichia coli at Hospital Tuanku Ja’afar Seremban (HTJS) / Marliana Mukhlas

Objectives. The aims of the present study were to estimate the prevalence of Extended- Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumonia and Escherichia coli in Hospital Tuanku Ja’afar Seremban from April to August.

Methods. This present study was a cross-sectional study. Total of 452 cases of Klebsiella pneumonia and Escherichia Coli reported were collected for analysis of ESBL production. The cases were taken randomly within April to August 2014 to fulfill minimum 50 cases. All cases were taken from demographic data from Department of Microbiology at Hospital Tuanku Ja’afar Seremban

Results. From 452 cases of Klebsiella pneumonia and Escherichia coli recorded, 196 cases were Klebsiella pneumonia and 256 were Escherichia coli. Out of 196 cases for Klebsiella pneumonia, only 91 of them were ESBL cases and 73 cases of ESBL for Escherichia coli out of 256 isolates. Male patients are most common being infected by ESBL-producing Klebsiella pneumonia and Escherichia coli with 59.1% compared to female patients, 40.9%. The most common age groups which were infected by ESBL-producing Klebsiella pneumonia and Escherichia coli was age ranging from 30’s to 45’s with 27.4% while the least age group infected by this organisms were 45’s to 60’s with 14.0%. Pattern of antibiotic resistances showed that ESBL-producing bacteria resist towards ampicillin (AMP) and most of them show resistances towards cefuroxime (CXM), cefotaxime (CTX) and ceftazidime (CAZ).