Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan

Nanoemulsion is a type of emulsion. It consist of fine oil-in-water dispersions, with the droplets covering the size range of 20-200nm. It can be achieved through emulsification process. One of the processes is through high-pressure homogenizer (HPH). The mechanical effect of HPH governs nanoemulsion properties such as stability, partical size and uniformity. Consequently, the specific mechanical effects during emulsification are the interest when well-defined nanoemulsion properties are needed. Therefore, in this work, nanoemulsion study consisting of water, waglinol oil and a mixture of nonionic surfactants using HPH was performed. The optimum formulation was developed by direct emulsification which consists of waglinol oil, tween 80, span 80 and distilled water (2: 0.8: 0.2: 7). Waglinol oil pre-emulsion were homogenized at various pressures ranging from 40 MPa to 80 MPa using a lab scale HPH. Different cycles were applied ranging from O to 15 cycles. The influence of homogenizing pressure on the size, stability and zeta potential were determined. The size of the nanoemulsion does not differ relatively as the pressure and cycle of the HPH increase. The zeta potential of nanoemulsions are negative. Furthermore, different pressure and cycle of HPH produces different stability rate.