Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek

UNSPECIFIED and Noorsal, Emilia and Ibrahim, Mohammad Nizam and Abd Manaf, Asrulnizam (2013) Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek. Esteem Academic Journal, 9 (1). pp. 1-11. ISSN 1675-7939

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Abstract

Silicon, glass, and ceramic are commonly used base substrates for gold (Au) deposition on label-free DNA biosensors. This study aimed to investigate the suitability of applying flame retardant 4 (FR4) as a base substrate and polydimethylsiloxane (PDMS) as a coating substrate. A thermal evaporator was used to fabricate copper/nickel/Au metals and ensure even deposition of Au throughout FR4. UV exposure soft lithography and wet etching were applied to develop a three-electrode pattern on the metals fabricated on FR4. A simple and straightforward technique on PDMS–FR4 bonding was proved to work at the shear strength of 55 kPa. A cyclic voltammetry (CV) method was performed using the fabricated FR4 sensor to analyze bare Au, DNA immobilization and hybridization. The FR4-based Au fabricated with PDMS acted as a coating layer between terminals and sensing electrodes, and can thus be used as a label-free DNA sensor.

Item Type: Article
Creators:
CreatorsEmail
UNSPECIFIEDUNSPECIFIED
Noorsal, EmiliaUNSPECIFIED
Ibrahim, Mohammad NizamUNSPECIFIED
Abd Manaf, AsrulnizamUNSPECIFIED
Subjects: T Technology > TK Electrical engineering. Electronics. Nuclear engineering
Divisions: Universiti Teknologi MARA, Pulau Pinang
Journal or Publication Title: Esteem Academic Journal
ISSN: 1675-7939
Volume: 9
Number: 1
Page Range: pp. 1-11
Item ID: 8898
Uncontrolled Keywords: flame retardant 4; polydimethylsiloxane; cyclic voltammetry; immobilization; hybridization
Last Modified: 04 Oct 2017 04:12
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/8898

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