Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan

Mokhtar, Marina and Adnan, Rohana (2012) Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan. Esteem Academic Journal, 8 (2). pp. 50-63. ISSN 1675-7939

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Abstract

Theophylline is a therapy for respiratory diseases which has limited use due to its rapid absorption and becomes inactive metabolite as methyluric acid when administered in the body system. These limitations can be reduced by complexation with inclusion of the beta cyclodextrin. The complex was prepared by kneading, slow evaporation and freeze drying methods. The structure of the complex was determined by FT-IR, DSC and 1H NMR. The molecular modeling study indicated theophylline lies exactly in the cavity of β-CD with hydrogen bonding.

Item Type: Article
Creators:
CreatorsEmail
Mokhtar, MarinaUNSPECIFIED
Adnan, RohanaUNSPECIFIED
Divisions: Universiti Teknologi MARA, Pulau Pinang > Permatang Pauh Campus
Journal or Publication Title: Esteem Academic Journal
ISSN: 1675-7939
Volume: 8
Number: 2
Page Range: pp. 50-63
Item ID: 8863
Uncontrolled Keywords: theophylline; inclusion complex; beta cyclodextrin; host-guest system
Last Modified: 19 Sep 2017 09:12
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/8863

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