Tocotrienols and Oxidative stress in oocytes and developing embryos / Yuhaniza Shafinie Kamsani and Mohd Hamim Rajikin.

Kamsani, Yuhaniza Shafinie and Rajikin, Mohd Hamim (2017) Tocotrienols and Oxidative stress in oocytes and developing embryos / Yuhaniza Shafinie Kamsani and Mohd Hamim Rajikin. Journal of Clinical and Health Science, 2 (2). pp. 1-11. ISSN 0127 – 984X

Abstract

This review summarizes the impact of tocotrienols (TCTs) as antioxidants in minimizing oxidative stress (OS), particularly in embryos exposed to OS causing agents. OS level is increased, for example, by nicotine, a major alkaloid content in cigarette, which is also a source of exogenous reactive oxygen species (ROS). Increased nicotine-induced OS increases cell stress response, which is a common trigger leading to embryonic cell death. Having more profound anti-oxidative stress effects than its counterpart tocopherol, TCTs improve blastocyst implantation, foetal growth, pregnancy outcome and survival of the neonates affected by nicotine. In reversing cell developmental arrest caused by nicotine-induced OS, TCTs enhances PDK-1 expression in the P13K/Akt pathway and permit embryonic development beyond the 4- cell stage with the production of more morulae. At the cytoskeletal level, TCTs increase the number of nicotine-induced apoptotic cells, through caspase 8 activation in the mitochondria. TCTs facilitate rough endoplasmic reticulum (rER) stress-mediated apoptosis and autophagy, resulting from nicotine-induced OS. Reduced vesicular population in TCT supplemented oocytes on the other hand may suggest reduced secretion of apoptotic cell bodies thus probably minimizing vesicular apoptosis during oocyte maturation. Further extensive research is required to develop TCTs as a tool in specific therapeutic approaches to overcome the detrimental effects of OS.

Metadata

Item Type: Article
Creators:
CreatorsID Num. / Email
Kamsani, Yuhaniza ShafinieUNSPECIFIED
Rajikin, Mohd HamimUNSPECIFIED
Subjects: Q Science > QP Physiology > Animal biochemistry
Q Science > QP Physiology > Animal biochemistry > Organic substances
Q Science > QP Physiology > Animal biochemistry > Organic substances > Vitamins
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Medicine
Journal or Publication Title: Journal of Clinical and Health Science
Journal: UiTM Journal > Journal of Clinical and Health Sciences
ISSN: 0127 – 984X
Volume: 2
Number: 2
Page Range: pp. 1-11
Official URL: https://jchs-medicine.uitm.edu.my/images/manuscrip...
Item ID: 30118
Uncontrolled Keywords: Nicotine, oxidative stress, tocotrienols, antioxidant, mitochondria, rough endoplasmic reticulum, vesicle.
URI: http://ir.uitm.edu.my/id/eprint/30118

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