IOP lowering effects of ocimum basilicum seed extract in two rabbit models of ocular hypertension / Renu Agarwal … [et al.]

Agarwal, Renu and Gupta, SK and Srivastava, Sushma and Saxena, Rohit (2019) IOP lowering effects of ocimum basilicum seed extract in two rabbit models of ocular hypertension / Renu Agarwal … [et al.]. Journal of Clinical and Health Science, 4 (1). pp. 1-8. ISSN 0127 – 984X

Abstract

Ocimum basilicum (OB), a herb known for its antihypertensive, anticholinesterase and antioxidant properties was investigated for possible intraocular pressure (IOP) lowering effects in rabbits with ocular hypertension (OHT). Methods: The IOP lowering effect of a single drop of OB extract (OBE) was evaluated in oculonormotensive rabbits using three concentrations (0.25, 0.5 and 1% w/v). The concentration showing maximum IOP reduction was further evaluated in rabbits with water-loading and steroidinduced OHT. Results: IOP lowering effect of OBE 0.5% in oculonormotensive rabbit eyes was significantly greater compared to OBE 0.25% (p0.05) to OBE 1%. Therefore, 0.5% concentration was selected for further evaluation. Pretreatment with OBE (0.5%) caused significantly lower increase in IOP after water loading amounting to 23.39% above baseline as compared to 54.00% in control eye, 15 minutes post water loading. At 60 minutes, post water loading, mean IOP rise was 95.12% and 63.58% in control and test eyes, respectively. Significant difference between the mean IOP of two eyes persisted during the 2nd hr. In rabbits with steroid induced OHT, OBE 0.5% produced a mean IOP reduction of 24.73% at the end of first hr and the mean peak IOP reduction of 31.63% was observed at the end of 2 hr. A significant difference between the IOP of test and control eyes persisted from 1 to 6 hr. Conclusions: Ocimum basilicum seed extract showed significant IOP lowering effect in rabbits with water loading and steroid induced OHT, however, its utility as an effective antiglaucoma medication needs further investigations.

Metadata

Item Type: Article
Creators:
CreatorsID Num. / Email
Agarwal, RenuUNSPECIFIED
Gupta, SKUNSPECIFIED
Srivastava, SushmaUNSPECIFIED
Saxena, RohitUNSPECIFIED
Subjects: R Medicine > RC Internal Medicine
R Medicine > RC Internal Medicine > Hypertension
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Medicine
Journal or Publication Title: Journal of Clinical and Health Science
Journal: UiTM Journal > Journal of Clinical and Health Sciences
ISSN: 0127 – 984X
Volume: 4
Number: 1
Page Range: pp. 1-8
Official URL: https://jchs-medicine.uitm.edu.my/images/manuscrip...
Item ID: 30107
Uncontrolled Keywords: Ocimum basilicum, experimental glaucoma, water loading-induced, rabbits
URI: http://ir.uitm.edu.my/id/eprint/30107

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