Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani

H. Sahabudin, Adzly and Foong, Fiona How Ni and Abdul Ghani, Radiah (2017) Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani. ESTEEM Academic Journal, 13. pp. 91-97. ISSN 1675-7939

Official URL: http://uppp.uitm.edu.my

Abstract

Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogues was succesfully synthesis with the expected structures

Metadata

Item Type: Article
Creators:
CreatorsID Num. / Email
H. Sahabudin, Adzlyadzlyhairee92@gmail.com
Foong, Fiona How Nihowfiona@iium.edu.my
Abdul Ghani, Radiahradiah@iium.edu.my
Subjects: R Medicine > RC Internal Medicine > Cancer
R Medicine > RC Internal Medicine > Cancer > Research. Experimentation
T Technology > TP Chemical technology > Biotechnology
Divisions: Universiti Teknologi MARA, Pulau Pinang > Permatang Pauh Campus
Journal or Publication Title: ESTEEM Academic Journal
Journal: UiTM Journal > ESTEEM Academic Journal
ISSN: 1675-7939
Volume: 13
Page Range: pp. 91-97
Official URL: http://uppp.uitm.edu.my
Item ID: 28775
Uncontrolled Keywords: Polyamine moiety, Putrescine-sulfur compounds, Polyamine-sulfur derivatives, Sulfur containing compounds, Structural determination
URI: http://ir.uitm.edu.my/id/eprint/28775

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