Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria

Zakaria, Zabliza (2010) Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria. Masters thesis, Universiti Teknologi MARA.

Abstract

The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride.

Metadata

Item Type: Thesis (Masters)
Creators:
CreatorsID Num. / Email
Zakaria, ZablizaUNSPECIFIED
Subjects: R Medicine > RS Pharmacy and materia medica > Materia medica
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Item ID: 27661
Uncontrolled Keywords: Chitosan, Microwave, Extrusion-spheronization
URI: http://ir.uitm.edu.my/id/eprint/27661

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