Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin

Nik Azmin, Nik Fatini (2018) Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin. In: The Doctoral Research Abstracts. IGS Biannual Publication, 14 . Institute of Graduate Studies, UiTM, Shah Alam.

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Abstract

In the present work, phytochemical and pharmacological studies were conducted on four species of plants from three different families. The studied plant samples were the air-dried lianas of two species from Gnetaceae family which are Gnetum microcarpum Blume and Gnetum cuspidatum Blume and the twigs of Cynometra cauliflora Linn from the family of Fabacaeae and Bouea oppositifolia (Roxb.) Meisn from the family of Anacardiaceae. The aims of this study are to isolate the secondary metabolites from the plants, to propose biogenetic pathway of the new isolated compounds, to determine their DPPH scavenging, PGE2 inhibitory and cytotoxic activities and to study the Structure-Activity Relationship (SAR). The isolation process was done by conventional method of maceration, fractionation, separation and purification using several chromatographic techniques and structural elucidation was based on the spectroscopic data evidences and comparison with reported authentic data. Phytochemicals investigation on the lianas of the two Gnetum species yielded 11 known stilbenoid compounds; resveratrol (1), isorhapontigenin (3), gnetol (10), gnetifolin P (18), gnetofuran C (20), gnetucleistol C (21), cuspidan B (24), e-viniferin (31), parvifolol D (44), gnemonol M (48) and malaysianol D (388), two new compounds from G. microcarpum characterized as malaysianol E (25), malaysianol F (389) and one new compound from G. cuspidatum, namely malaysianol G (399). Phytochemicals investigation on C. cauliflora and B. oppositifolia gave 16 known flavonoid compounds; naringenin (263) and eriodictyol (262) were obtained from both species; flavone apigenin, acacetin, luteolin, luteolin 3',5 dimethyl ether, 3',4',7-trihydroxyflavone, 4',7-dihydroxyflavone (392-397) and 5,7-dihydroxychromone (391) from C. cauliflora; chalcone isoliquiritigenin (398), flavanone liquiritigenin and butin (399-400), flavanol taxifolin (260), fustin, garbanzol (401-402) and aurone sulfuretin (403) from B. oppositifolia…

Item Type: Book Section
Creators:
CreatorsID Num.
Nik Azmin, Nik FatiniUNSPECIFIED
Subjects: Q Science > QR Microbiology > Immunology
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 14
Item ID: 22025
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia; biological activities
Last Modified: 12 Nov 2018 06:57
Depositing User: Staf Pendigitalan 5
URI: http://ir.uitm.edu.my/id/eprint/22025

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