Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi

Meor Mohd Affandi, Meor Mohd Redzuan (2016) Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi. In: The Doctoral Research Abstracts. IGS Biannual Publication, 10 (10). Institute of Graduate Studies, UiTM, Shah Alam.

Abstract

Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statins exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. As a consequence, abundant studies are available in regard to the solubility enhancement of statins but very few actually describe this phenomenon in terms of thermodynamics and the solute solvent interaction. The present study aimed to elucidate the solute-solvent and solute-cosolute interactions, solid state characteristics, wetting behaviour, surface energy and thermodynamic parameters that bolstered the solubility of simvastatin (SMV) and atorvastatin (ATV) in the presence of ARG. First, the solubility of SMV and ATV in 0.01, 0.02, 0.04, 0.09, 0.18, 0.36 and 0.73 mol dm-3 arginine (ARG) in water solutions was determined. These solutions were subjected to conductometric, volumetric, viscometric, acoustic and refractometric measurements at temperatures (T) of 298.15, 303.15, 308.15 and 313.15 K. Results indicated that there was a massive increase of SMV and ATV solubility in the presence of ARG as a cosolute. Based on physical characteristics, a strong solute-solvent and solutecosolute interaction has occurred in the SMV-ARG and ATV-ARG binary solution mixture…

Metadata

Item Type: Book Section
Creators:
CreatorsID Num. / Email
Meor Mohd Affandi, Meor Mohd RedzuanUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Universiti Teknologi MARA, Shah Alam > Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 10
Number: 10
Item ID: 19924
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM;
URI: http://ir.uitm.edu.my/id/eprint/19924

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