New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti

Camillo, Benetti (2016) New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti. In: The Doctoral Research Abstracts. IGS Biannual Publication, 10 (10). Institute of Graduate Studies, UiTM, Shah Alam.


Dome Matrix technology is a platform for the controlled release of drug. This technology is based on the assembling of modules used as elements for controlling the drug release. The research project of the doctorate thesis was devoted to the application of Dome Matrix technology for the preparation of gastro-retentive dosage forms thanks to the module assembly in void configuration. According to the co-tutorship agreement, the research was carried out both at University of Parma and University Teknologi MARA, Kuala Lumpur. During the first part of the project, carried out at University of Parma, a modular assembled system for a double pulse release (immediate and delayed release) of esomeprazole in combination with sucralfate was studied. The assembled system was build up by assembling 5 modules, three sucralfate modules and two esomeprazole modules, in “mixed” configuration (void and stacked configurations) with three different release kinetics. The alkalizing agent in the esomeprazole immediate release module prevented the degradation of the drug in acid environment in vitro…


Item Type: Book Section
CreatorsEmail / ID. Num
Camillo, BenettiUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Universiti Teknologi MARA, Shah Alam > Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 10
Number: 10
Item ID: 19907
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM;



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