Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed

Mohamed, Nor Izwani (2017) Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam.

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Abstract

Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges to effective tamoxifen therapy include drug resistance, and adverse events. Thus, this study aims to investigate the impact of pharmacogenomics and metabolomics in monitoring the efficacy of tamoxifen treatment in BRCA patients. A total of 95 tamoxifen-treated patients, and 11 untreated breast cancer patients from three major Malaysian ethnic groups (Malay, Chinese and Indian) were recruited. However, only 84 tamoxifen-treated patients with completed clinical data were included for clinical association analysis.

Item Type: Book Section
Creators:
CreatorsEmail
Mohamed, Nor IzwaniUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
R Medicine > RC Internal Medicine > Cancer > Research. Experimentation
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 12
Number: 12
Item ID: 19903
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM
Last Modified: 08 Jun 2018 03:55
Depositing User: Staf Pendigitalan 2
URI: http://ir.uitm.edu.my/id/eprint/19903

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