Cellular responses of normal human osteoblasts to multiple environmental stressors in vitro / Aisha Mohd Din

Mohd Din, Aisha (2017) Cellular responses of normal human osteoblasts to multiple environmental stressors in vitro / Aisha Mohd Din. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam.

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Abstract

Cells respond to environmental stress via the activation of various survival pathways and may possibly end with the initiation of cell death in order to eliminate damaged cells. The ability of cells to mount an adaptive or destructive response depends on the type and duration of the stress. The response to continuous orbital fluid shear stress (OFSS), moderate hypothermia (35°C) and moderate hyperthermia (39°) in this study demonstrated an anabolic effect on Normal Human Osteoblast (NHOst) cells where the cell metabolism, differentiation and proliferation was either promoted or retained. The anabolic effect correlated with an inhibition of osteoclast activity by reducing the RANKL/OPG ratio. In response to 3 days of OFSS, increase in NHOst mitochondrial metabolism and proliferation simultaneously prevented apoptosis. Meanwhile the increase in alkaline phosphatase (ALP) activity and osteocalcin (OCN) after recovery from OFSS suggested that NHOst function was promoted.

Item Type: Book Section
Creators:
CreatorsEmail
Mohd Din, AishaUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 12
Number: 12
Item ID: 19825
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM
Last Modified: 08 Jun 2018 01:17
Depositing User: Staf Pendigitalan 2
URI: http://ir.uitm.edu.my/id/eprint/19825

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