Whole genome sequencing and analysis on the trios of the Che Wong and Semai:understanding the medico-genomic association / Rose Iszati Ismet Nayan

Ismet Nayan, Rose Iszati (2017) Whole genome sequencing and analysis on the trios of the Che Wong and Semai:understanding the medico-genomic association / Rose Iszati Ismet Nayan. In: The Doctoral Research Abstracts. IGS Biannual Publication, 11 (11). Institute of Graduate Studies, UiTM, Shah Alam.

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Abstract

As to date, there is no report on the architecture of the whole genomes of the unique Orang Asli subtribes in Peninsular Malaysia. The Che Wong was selected as the group of interest as they have a dwindling population of 651, while the Semai Orang Asli with a population number of 51,313 was selected as the control group. The Semai is the largest sub-tribe of the Senoi which is also the largest group amongst the Orang Asli. This study aims to understand the variation in genomics composition of the Che Wong and Semai Orang Asli by a deep and systematic characterization of the genome through development of an in-house bioinformatics pipeline. The disease risk and protection conferred by genetic traits were explored via sequencing the whole genome of a trio family of both the Che Wong and Semai subtribes. The Che Wong and Semai genomes were sequenced and mapped to the human reference genome (hg19) with an average coverage of 44.1x and 43.0x, respectively. A total of ~6.23 million and ~6.18 million variants were identified for the Che Wong and Semai trios, respectively…

Item Type: Book Section
Creators:
CreatorsEmail
Ismet Nayan, Rose IszatiUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 11
Number: 11
Item ID: 19808
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM;
Last Modified: 08 Jun 2018 01:16
Depositing User: Staf Pendigitalan 5
URI: http://ir.uitm.edu.my/id/eprint/19808

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