Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi

Samat @ Darawi, Mohd Nazif (2014) Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.

Abstract

The incidence of Alzheimer”s disease (AD) is expected to increase exponentially as the population ages. Continuing research in this area is essential to better understand this disease and develop strategies for prevention and treatment. Recent genome-wide association studies have identified several novel loci as genetic risk factors of AD. Previous studies also suggest the total plasma homocysteine (tHcy) level and its biological determinants such as folate and vitamin B12 contribute to the risk of AD. Some of them highlight the correlation between AD risk and genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and transcobalamin (TCN II) since they are directly associated with the Hcy metabolism.

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Metadata

Item Type: Book Section
Creators:
CreatorsID Num.
Samat @ Darawi, Mohd NazifUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IPSis Biannual Publication
Volume: 6
Number: 6
Item ID: 19626
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM
URI: http://ir.uitm.edu.my/id/eprint/19626

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