Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby

Elyagoby, Assad Ali Faraj (2014) Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.

Abstract

Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-fluorouracil. The solid coating powder was constituted of ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to spheroids was varied between 2:3 and 3:2. Delayed 5-fluorouracil release was obtained when the weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3, and weight ratio of solid coating powder to spheroids was kept at 3:2 with particle size of ethylcellulose reduced to 22 μm.

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Metadata

Item Type: Book Section
Creators:
CreatorsID Num.
Elyagoby, Assad Ali FarajUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IPSis Biannual Publication
Volume: 6
Number: 6
Item ID: 19620
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; Colon-specific delivery
URI: http://ir.uitm.edu.my/id/eprint/19620

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