Gamma-tocotrienol reverses nicotine-induced oxidatives stress-related in vitro and in vivo embryonic development and pregnancy outcome in mice / Yuhaniza Shafinie Kamsani

Kamsani, Yuhaniza Shafinie (2014) Gamma-tocotrienol reverses nicotine-induced oxidatives stress-related in vitro and in vivo embryonic development and pregnancy outcome in mice / Yuhaniza Shafinie Kamsani. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.

Abstract

A study to evaluate the effects of nicotine and simultaneous supplementation of γ-tocotrienol (γ-TCT), one of the four isomers in tocotrienols (TCT), and nicotine, on in vitro and in vivo embryonic development in mice (Mus musculus) had been carried out. Several approaches were undertaken including an investigation on in vitro effects of various doses and durations of nicotine treatment on pre-implantation embryonic development. Results showed that nicotine treatment decreased the number of retrieved embryos, resulted embryo degeneration, delayed embryo cleavage, induced disproportionate size of blastomeres and degraded blastomeres (p<0.05). Moreover, the deleterious impact of nicotine on pre-implantation embryonic development was dose- and treatment duration-dependent with a corresponding increase in plasma malondialdehyde (MDA) concentrations (p<0.05). Based on this finding, the study was further elucidated in terms of examining the dose-related beneficial effects of γ–TCT in nicotineinduced cessation of pre-implantation embryonic development in vitro.

Metadata

Item Type: Book Section
Creators:
CreatorsEmail / ID. Num
Kamsani, Yuhaniza ShafinieUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Universiti Teknologi MARA, Shah Alam > Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IPSis Biannual Publication
Volume: 6
Number: 6
Item ID: 19619
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; vivo embryonic development
URI: http://ir.uitm.edu.my/id/eprint/19619

Download

[img]
Preview
Text
ABS_YUHANIZA SHAFINIE KAMSANI TDRA VOL 6 IGS_14.pdf

Download (433kB) | Preview

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year