Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim

Ibrahim, Hisham Saleh (2014) Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.

Abstract

Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP).

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Metadata

Item Type: Book Section
Creators:
CreatorsID Num.
Ibrahim, Hisham SalehUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IPSis Biannual Publication
Volume: 6
Number: 6
Item ID: 19615
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; Endothelial activation
URI: http://ir.uitm.edu.my/id/eprint/19615

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