Screening for β-lactamase inhibitors from mangrove soil actinomycetes / Suhaidi Ariffin

Ariffin, Suhaidi (2016) Screening for β-lactamase inhibitors from mangrove soil actinomycetes / Suhaidi Ariffin. In: The Doctoral Research Abstracts. IGS Biannual Publication, 9 (9). Institute of Graduate Studies, UiTM, Shah Alam.


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Marine-derived actinomycetes possess distinct and complex metabolic capabilities, resulting in the wide diversity of their secondary metabolites in terms of chemical structure and biological activity. The bioactive compounds of actinomycetes isolated from mangrove soils are reported to possess various biological activities such as antimicrobial, cytotoxicity, anticancer and antioxidant. The aims of this study are to isolate and characterize diverse populations of marine actinomycetes from mangrove soils, to identify selected morphologically distinct isolates by using 16S rRNA sequence analysis, to screen their potential biological activities as antimicrobial as well as β-lactamase inhibitor agents, and to elucidate the structure of selected bioactive compounds. A total of 73 actinomycete strains were isolated from 11 mangrove locations in Malaysia. Of these, morphological observations and 16S rRNA sequence analysis indicate the presence of representative species from at least 3 genera Streptomyces, Pseudonocardia and Saccharomonospora. The majority of the isolates belong to genus Streptomyces. It was found that the most productive medium for isolation is starch casein nitrate agar (SCNA)…

Item Type: Book Section
Ariffin, SuhaidiUNSPECIFIED
Subjects: L Education > LB Theory and practice of education > Higher Education > Dissertations, Academic. Preparation of theses > Malaysia
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 9
Number: 9
Item ID: 19600
Uncontrolled Keywords: Abstract; Abstract of thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM; β-lactamase
Last Modified: 07 Jun 2018 02:19
Depositing User: Staf Pendigitalan 7

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