Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol

Saleh Elghuol, Maati Musbah (2017) Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, Shah Alam.

[img] Text (ABSTRACT ONLY)
ABS_MAATI MUSBAH SALEH ELGHUOL TDRA VOL 12 IGS 17.pdf - Submitted Version

Download (0B)

Abstract

This study was conducted with the hypothesis that the phytochemical closely related to Libyan medicinal herb, Urginea maritima (L.) Baker constituents within water-based extract would own appropriately powerful properties that contribute to intrinsic regulation specific antitumour activities in human malignant SH-SY5Y neuroblastoma cells. The purpose of the present study was to explore the characterisation and identification of the major phytochemical of the U. maritima aqueous extract. Additionally, the study also aimed to evaluate their effectiveness on the cellular and molecular mechanism associated with the main anti-tumour criteria. Through utilising several in-vitro techniques on both the experimental cell line models involving (2× 104 to 1× 106 cells/ml) with the quality of ≥ 90% viability of SH-SY5Y neuroblastoma and RA differentiated (neuronmodel) cells. Evaluation of the impact of the active extract ingredients was conducted based on morphological observation, biochemical, cellular function and gene expression profile, and the analysis was carried out for its estimation within different concentrations and durations. Neuroblastoma is a well-known extra-cranial solid tumour and one of the most deadly malignancies in childhood.

Item Type: Book Section
Creators:
CreatorsEmail
Saleh Elghuol, Maati MusbahUNSPECIFIED
Subjects: Q Science > QM Human anatomy
R Medicine > RC Internal Medicine > Cancer
Divisions: Institut Pengajian Siswazah (IPSis) : Institute of Graduate Studies (IGS)
Series Name: IGS Biannual Publication
Volume: 12
Number: 12
Item ID: 18922
Uncontrolled Keywords: Abstract; Abstract of Thesis; Newsletter; Research information; Doctoral graduates; IPSis; IGS; UiTM
Last Modified: 25 Jan 2018 08:58
Depositing User: Admin Pendigitan 2 PTAR
URI: http://ir.uitm.edu.my/id/eprint/18922

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year