Enzymatic reaction of betulinic acid with acyl chloride: synthesis of anti-cancer compound / Yamin Yasin

Yasin, Yamin (2011) Enzymatic reaction of betulinic acid with acyl chloride: synthesis of anti-cancer compound / Yamin Yasin. Research Reports. Research Management Institute (RMI), Shah Alam. (Unpublished)

Abstract

Betulinic acid, 3β-hydroxy-lup-20(29)-ene-28-oic acid (1), is a natural product which can be isolated from several genus of higher plants. Betulinic acid has been shown to exhibit a variety of biological activities. It was found to be an excellent anti-tumor agent due to its unique in vitro and in vivo cytotoxicity profile. Betulinic acid was also found to have activity and inhibition against human immunodeficiency virus (HIV) replication in lymphocyte cells, blockage of HIV-1 entry into cells and cytotoxicity against a variety of cultured human tumor cells (Bringmann et al., 1997).

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Metadata

Item Type: Monograph (Research Reports)
Creators:
CreatorsID Num.
Yasin, YaminUNSPECIFIED
Divisions: Research Management Institute (RMI)
Item ID: 16844
Uncontrolled Keywords: Enzymatic reaction; Anti-cancer compound
URI: http://ir.uitm.edu.my/id/eprint/16844

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