Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek

Raja Yahya, Mohd Fakharul Zaman and Mohd Sidek, Hasidah (2012) Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek. Scientific Research Journal, 9 (1). pp. 1-14. ISSN 1675-7009

[img] Text
AJ_MOHD FAKHARUL ZAMAN RAJA YAHYA SRJ 12 1.pdf

Download (791kB)

Abstract

Malaria parasites, Plasmodium can infect a wide range of hosts including humans and rodents. There are two copies of mitogen activated protein kinases (MAPKs) in Plasmodium, namely MAPK1 and MAPK2. The MAPKs have been studied extensively in the human Plasmodium, P. falciparum. However, the MAPKs from other Plasmodium species have not been characterized and it is therefore the premise of presented study to characterize the MAPKs from other Plasmodium species-P. vivax, P. knowlesi, P. berghei, P. chabaudi and P.yoelli using a series of publicly available bioinformatic tools. In silico data indicates that all Plasmodium MAPKs are nuclear-localizedandcontain both a nuclear localization signal (NLS) anda Leucine-rich nuclear export signal (NES). The activation motifs ofTDYand TSH werefound to befully conserved in Plasmodium MAPK1 and MAPK2, respectively.

Item Type: Article
Creators:
CreatorsID Num.
Raja Yahya, Mohd Fakharul Zamanfakharulzaman@salam.uitm.edu.my
Mohd Sidek, HasidahUNSPECIFIED
Subjects: Q Science > QP Physiology > Animal biochemistry > Protein kinases
Q Science > QR Microbiology > Plasmodium falciparum
R Medicine > RC Internal Medicine > Chronic diseases > Malaria
Divisions: Research Management Institute (RMI)
Journal or Publication Title: Scientific Research Journal
ISSN: 1675-7009
Volume: 9
Number: 1
Page Range: pp. 1-14
Item ID: 12954
Uncontrolled Keywords: Malaria, Plasmodium, Signal Transduction, Protein Kinase, Mitogen acitivated protein kinase.
Last Modified: 21 Feb 2017 03:53
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/12954

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year