Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]

Mazalan, Norfaezah and Mat Zain, Mazatulikhma and Jumali, Nor Saliyana and Mohalid, Norhanim and Shameri, Zurina and Hamzah, Ahmad Sazali (2011) Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]. Scientific Research Journal, 8 (2). pp. 33-47. ISSN 1675-7009

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Abstract

Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and extensively studied as novel drugs designed for cancer chemotherapy and brain delivery. Since polymers are going to be used in human, this study has the interest of testing two types of polymer, polyimides (PI) and polyphenylenevinylene (PPV) on neuronal cells. The objective of this study was to determine the possible neurotoxicity and potential neuroprotective effects of PI and PPV towards SH-SY5Y neuronal cells challenged by hydrogen peroxide (H2O2) as an oxidant. Cells were pretreated with either PI or PPV for 1 hour followed by incubation for 24 hour with 100 μM of H2O2. MTS assay was used to assess cell viability. Results show that PI and PPV are not harmful within the concentration up to 10 μM and 100 μM, respectively. However, PI and PPV do not protect neuronal cells against toxicity induced by H2O2 or further up the cell death.

Item Type: Article
Creators:
CreatorsID Num.
Mazalan, Norfaezahfaezahmazalan@yahoo.com
Mat Zain, MazatulikhmaUNSPECIFIED
Jumali, Nor SaliyanaUNSPECIFIED
Mohalid, NorhanimUNSPECIFIED
Shameri, ZurinaUNSPECIFIED
Hamzah, Ahmad SazaliUNSPECIFIED
Subjects: Q Science > QD Chemistry > Hydrogen peroxide
Q Science > QP Physiology > Neuroprotective agents
R Medicine > RC Internal Medicine > Neurotoxicology
T Technology > TP Chemical technology > Polyimides
Divisions: Research Management Institute (RMI)
Journal or Publication Title: Scientific Research Journal
ISSN: 1675-7009
Volume: 8
Number: 2
Page Range: pp. 33-47
Item ID: 12948
Uncontrolled Keywords: Neurotoxicity, Neuroprotection, Polyimide (PI), Polyphenylenevinylene (PPV), and Hydrogen Peroxide
Last Modified: 30 May 2016 02:41
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/12948

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