Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad

Ahmad, Faujan (2010) Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad. Scientific Research Journal, 7 (1). pp. 65-76. ISSN 1675-7009

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Abstract

Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid.

Item Type: Article
Creators:
CreatorsEmail
Ahmad, Faujanyamin961@salam.uitm.edu.my
Subjects: T Technology > TP Chemical technology > Enzymes
Divisions: Research Management Institute (RMI)
Journal or Publication Title: Scientific Research Journal
ISSN: 1675-7009
Volume: 7
Number: 1
Page Range: pp. 65-76
Item ID: 12932
Uncontrolled Keywords: Betulinic acid, betulinic acid derivatives, enzymatic synthesis, cytotoxic activity
Last Modified: 28 Mar 2019 02:45
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/12932

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