Enzymatic reaction of betulinic acid with acyl chloride: synthesis of anti-cancer compound / Yamin Yasin

Yasin, Yamin (2011) Enzymatic reaction of betulinic acid with acyl chloride: synthesis of anti-cancer compound / Yamin Yasin. Research Reports. Research Management Institute (RMI), Shah Alam. (Unpublished)

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Abstract

Betulinic acid, 3β-hydroxy-lup-20(29)-ene-28-oic acid (1), is a natural product which can be isolated from several genus of higher plants. Betulinic acid has been shown to exhibit a variety of biological activities. It was found to be an excellent anti-tumor agent due to its unique in vitro and in vivo cytotoxicity profile. Betulinic acid was also found to have activity and inhibition against human immunodeficiency virus (HIV) replication in lymphocyte cells, blockage of HIV-1 entry into cells and cytotoxicity against a variety of cultured human tumor cells (Bringmann et al., 1997).

Item Type: Monograph (Research Reports)
Uncontrolled Keywords: Enzymatic reaction; Anti-cancer compound
Subjects: Q Science > QP Physiology > Animal biochemistry > Organic substances
R Medicine > RC Internal Medicine > Cancer
Divisions: Research Management Institute (RMI)
Depositing User: Staf Pendigitalan 5
Date Deposited: 09 May 2017 09:28
Last Modified: 09 May 2017 09:28
URI: http://ir.uitm.edu.my/id/eprint/16844

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