Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.]

Barkatullah, Islam and Ahmad, Syed Shamshad and Akhtar, Kafil and Mansoor, Tariq (2021) Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.]. Journal of Clinical and Health Sciences, 6 (1). pp. 18-24. ISSN 0127 – 984X

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Abstract

Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance of serum HER-2/neu concentration with tissue HER-2/neu immunohistochemistry and determine its relationship with various prognostic indicators like age, size of tumour, lymph node status, grade, and stage of tumour. Methods: The preoperative serum samples of 56 clinically and cytologically diagnosed cases of breast carcinoma were taken and postoperative mastectomy specimens were examined for the histologic type, lympho-vascular invasion, stage, and grade of the tumour. Immunohistochemical study of HER-2/neu expression and HER-2/neu serum biochemistry was studied. Results: Age of the patients ranged from 25-75 years. Twenty-three cases (41.1%) were premenopausal while 33 cases (58.9%) postmenopausal. Forty-seven cases (83.9%) were of the infiltrating ductal carcinoma (NOS) type. Serum positivity for HER-2/neu was noted in 29 (51.8%) cases. Serum HER-2/neu levels showed a positive correlation with increase in tumour size, grade, stage of tumour and lymph node involvement. Serum HER- 2/neu positivity was seen in 20 (68.9%) IHC positive patients and 9 (33.3%) IHC negative patients, with a statistically significant correlation (p=0.005). Conclusion: Serum HER-2/neu levels directly correlate with prognostic factors like tumour size, grade, stage of the tumour and lymph node metastasis and can be used as a complimentary tool to tissue HER-2/neu immunohistochemistry.

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Item Type: Article
Creators:
Creators
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Barkatullah, Islam
UNSPECIFIED
Ahmad, Syed Shamshad
UNSPECIFIED
Akhtar, Kafil
UNSPECIFIED
Mansoor, Tariq
UNSPECIFIED
Subjects: R Medicine > RG Gynecology and obstetrics > Diseases of the breast
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Medicine
Journal or Publication Title: Journal of Clinical and Health Sciences
UiTM Journal Collections: UiTM Journal > Journal of Clinical and Health Sciences (JCHS)
ISSN: 0127 – 984X
Volume: 6
Number: 1
Page Range: pp. 18-24
Official URL: https://jchs-medicine.uitm.edu.my/index.php
Item ID: 44352
Uncontrolled Keywords: Carcinoma Breast, Her-2/neu, Serum, Immunohistochemistry
URI: https://ir.uitm.edu.my/id/eprint/44352

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44352

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