Endocrinopathies in HIV Infected Patients / Rosdina Zamrud Ahmad Akbar ... [et al.]

Ahmad Akbar, Rosdina Zamrud and Wan Muhammad Hatta, Sharifah Faradila and Mohd Noh, Rosnida and Mohd Shah, Fatimah Zaherah and Abdul Rahman, Thuhairah and Abdul Ghani, Rohana and Ismail, Zaliha (2020) Endocrinopathies in HIV Infected Patients / Rosdina Zamrud Ahmad Akbar ... [et al.]. Journal of Clinical and Health Sciences, 5 (2). pp. 39-45. ISSN 0127 – 984X

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Abstract

Introduction: Hormonal abnormality is one of many clinical manifestations of HIV infections that is not well understood. However, the consequences could affect quality of life and are potentially treatable. Thus, this study aimed to determine the prevalence and associated factors of thyroid, adrenal and gonadal dysfunctions among HIV-infected patients. Methods: This is a single centre cross-sectional study involving 150 HIV-infected patients attending the HIV clinic. Each subject was required to answer specific symptoms questionnaire and their medical records were reviewed for relevant clinical and biochemical data. Blood for was collected and thyroid hormones, cortisol, ACTH, FSH, LH, testosterone and estradiol were analysed using electrochemiluminescent immunoassay. Thyroid, adrenal and gonadal axes abnormalities were identified. Results: Hypogonadism had the highest prevalence amongst the endocrine abnormalities, which was detected in 23 patients (15.3%), followed by thyroid dysfunction in 18 patients (12%) and hypocortisolism in 2 patients (1.3%). There was significant correlation between CD4 count, BMI and age with the hormone levels. Conclusion: Prevalence of endocrine abnormalities was low in these well-treated HIV-positive patients, with hypogonadism being the most common. However, significant correlations between CD4 count, age and BMI with the hormonal levels were detected. Clinical symptoms in relation to endocrinopathy are not specific as a screening tool thus underscoring the need for biochemical tests to identify these treatable conditions.

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Item Type: Article
Creators:
Creators
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Ahmad Akbar, Rosdina Zamrud
UNSPECIFIED
Wan Muhammad Hatta, Sharifah Faradila
UNSPECIFIED
Mohd Noh, Rosnida
UNSPECIFIED
Mohd Shah, Fatimah Zaherah
UNSPECIFIED
Abdul Rahman, Thuhairah
UNSPECIFIED
Abdul Ghani, Rohana
UNSPECIFIED
Ismail, Zaliha
UNSPECIFIED
Subjects: R Medicine > RA Public aspects of medicine > Toxicology. Poisons
R Medicine > RA Public aspects of medicine > AIDS. HIV infections
R Medicine > RC Internal Medicine > Specialties of internal medicine > Diseases of the endocrine glands. Clinical endocrinology
R Medicine > RC Internal Medicine > Specialties of internal medicine > Diseases of the genitourinary system. Urology
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Medicine
Journal or Publication Title: Journal of Clinical and Health Sciences
UiTM Journal Collections: UiTM Journal > Journal of Clinical and Health Sciences (JCHS)
ISSN: 0127 – 984X
Volume: 5
Number: 2
Page Range: pp. 39-45
Official URL: https://jchs-medicine.uitm.edu.my/index.php
Item ID: 44170
Uncontrolled Keywords: Hormone abnormalities, hypogonadism, thyroid dysfunction, adrenal dysfunction, HIV-infected patients
URI: https://ir.uitm.edu.my/id/eprint/44170

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44170

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