Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor

Mohd Shotor, Siti Noriah (2014) Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor. Masters thesis, Universiti Teknologi MARA.

Abstract

The synthesis and characterization of a series of hydroxamic acid namely benzohydroxamic acid (BHA), salicylhydroxamic acid (SHA) and their complexes with Cu(II), Co(II), V(IV), Zn(II), Fe(II), Ni(II) and Cr(III) are described herein. The characterization of the synthesized ligands and complexes were carried out by means of elemental analysis (C,H,N), ¹H and ¹³C NMR and IR spectroscopy, conductivity, magnetic susceptibility and melting point. Through IR and NMR studies, the synthesized ligands were shown to possess the carbonyl (CO) and hydroxylamine (NH₂-OH) groups, characteristics of hydroxamic acid. It was found that the dominant coordination mode in metal-hydroxamic acid complexes was the O, O ’-bidentate chelates in which the ligands were singly deprotonated (hydroxamato). The coordination through the carbonyl oxygen atom and the deprotonated hydroxy group showed a very stable five-membered chelate was formed. Moreover, depending on pH, two (0,0) bonding modes of the ligands are accessible to a series of metal ions like Cu(II), Cr(III), Zn(II), Fe(II) and VO(IV) where in this case, the synthesis took place in acidic environment which making the O, O-bonding modes were more favorable.

Metadata

Item Type: Thesis (Masters)
Creators:
Creators
Email / ID Num.
Mohd Shotor, Siti Noriah
UNSPECIFIED
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Programme: Master of Science (Inorganic Chemistry)
Keywords: Hydroxamic acid; Metal complexes; cytotoxicity; neurotoxicity study
Date: 2014
URI: https://ir.uitm.edu.my/id/eprint/18371
Edit Item
Edit Item

Download

[thumbnail of TM_SITI NORIAH MOHD SHOTOR AS 14_5.pdf] Text
TM_SITI NORIAH MOHD SHOTOR AS 14_5.pdf

Download (109kB)

Digital Copy

Digital (fulltext) is available at:

Physical Copy

Physical status and holdings:
Item Status:

ID Number

18371

Indexing

Statistic

Statistic details