Analysis of temperature response subject to Electromagnetic (EM) Field On Biological Tissue Using Bio-Heat Equation / Muhammad Aizzul Mohd Lazim, Nurul Ain Zainudin, Ain Norhanis Nordin

The success of hyperthermia treatment can be affected by thermal properties of biological tissues. Thus, the aim of this research is to investigate the influence of thermal properties on tissue during hyperthermia treatment. It was absolutely essential to know the suitable temperature within biological tissue as the success of hyperthermia treatment depends on it. In this study, the influence of thermal conductivity on temperature distribution in biological tissues has been examined. At the same time, the influence of blood perfusion term and external heat source on temperature distribution is also investigated. The effect of metabolic heat generation on temperature is also evaluated in this study. A finite difference method has been used to discretize the bio-heat equation and achieved the numerical solution of the problem. The reduced equation of second order ordinary differential equation is then solved by using toolbox ode45 in MATLAB. The results indicate that the increase of blood perfusion rate will decrease the tissues temperature while the temperature increases when the external heat increased. The study also found that the metabolic heat generation can be neglected. All the results for this study are simulated graphically and then discussed in detail. This study helps in understanding the temperature within tissue that can cause failure during hyperthermia treatment. Thus, the investigation on the influence of variable thermal properties is extremely beneficial for the clinical therapeutic application in the treatment of cancerous cells.