Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli

Mohd Zolkefpeli, Siti Noorafifah (2015) Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli. Masters thesis, Universiti Teknologi MARA.

[img]
Preview
Text
TM_SITI NOORAFIFAH MOHD ZOLKEFPELI PH 15_5.pdf

Download (1MB) | Preview

Abstract

Conventional spheroid preparation by extrusion-spheronization technique requires microcrystalline cellulose (MCC) as processing aid to improve extrudability of wet mass and spheronization capacity of extrudates. The present study investigated formulation and processing attributes in extrusion and spheronization necessary for design of MCC-free alginate spheroids. The physicochemical characteristics of these spheroids were examined and compared against MCC-Ioaded alginate spheroids using chlorpheniramine maleate and tolbutamide as water-soluble and poorly water-soluble drugs respectively. Alginate spheroids demonstrated a slower release of hydrophilic drug due to ease of matrix swelling and aggregation in the absence of MCC. This reduced their specific surface area for drug dissolution. Crosslinking of alginate with soluble calcium densified the surface of spheroids and hindered matrix aggregation. It led to faster drug release from alginate than alginate-MCC spheroids. Fast drug release was also noted in spheroids embedded with hydrophobic drug when MCC was absent as drug adsorbent. A complete replacement ofMCC with alginate can promote or retard drug release of spheroids as a function of drug-polymer interaction and state of matrix swelling and aggregation

Item Type: Thesis (Masters)
Uncontrolled Keywords: Microcrystalline cellulose (MCC); Extrusion and spheronization; f MCC-free alginate spheroids
Subjects: R Medicine > RS Pharmacy and materia medica > Materia medica
Divisions: Faculty of Pharmacy
Depositing User: Staf Pendigitan 2
Date Deposited: 22 Nov 2016 00:30
Last Modified: 22 Nov 2016 00:30
URI: http://ir.uitm.edu.my/id/eprint/15234

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year