Synthesis, characterization and biological activity of NitrogenOxygen-Sulfur (NOS) transition metal complexes derived from novel s-2,4-dichlorobenzyldithiocarbazate with 5-fluoroisatin / Mohd Abdul Fatah Abdul Manan ... [et al.]

Abdul Manan, Mohd Abdul Fatah and Bahron, Hadariah and Kassim, Karimah and Muhamad, Mohd Asrul Hafiz and Sayed Mohamad, Syed Nazmi (2010) Synthesis, characterization and biological activity of NitrogenOxygen-Sulfur (NOS) transition metal complexes derived from novel s-2,4-dichlorobenzyldithiocarbazate with 5-fluoroisatin / Mohd Abdul Fatah Abdul Manan ... [et al.]. Scientific Research Journal, 7 (2). pp. 67-90. ISSN 1675-7009

Official URL: https://srj.uitm.edu.my/

Abstract

A novel Schiff base containing nitrogen-oxygen-sulfur (NOS) donor atoms formed from the condensation reaction of S-2,4dichlorobenzyldithiocarbazate (S-2.4BDTC) with 5-fluroisatin has been synthesized. Complexes of cobalt(ll), nickel(ll), copper(ll), zinc(ll) and cadmium(ll) with this Schiff base have been prepared and characterized using elemental analysis and various physico-chemical techniques. In the cobalt(ll) andnickel(II) complexes the SchifJbase behaves as a uninegatively charged tridentate nitrogen-oxygen-sulfur (NOS) chelating ligand, bonding through the azomethine nitrogen, thiolate sulfur and carbonylic oxygen of the isatin moiety. However. in the copper(ll), zinc(II) and cadmium(II) complexes the Schiff base behaves as a nitrogen-sulfur (NS) bidentate chelating ligand, bonding through the azomethine nitrogen and thiolate sulfur. The Schiff base and the metal complexes were evaluated with respect to antimicrobial activity, which was performed in reallion to two selected pathogenic microbials (Bacillus subtilis and Pseudomonas aeruginosa). It was observed that only the zinc Schiffbase complex exhibited strong activity against the Bacillus subtilis bacteria with an inhibition zone of 25 mm.

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Abdul Manan, Mohd Abdul Fatah
abdfatah@salam.uitm.edu.my
Bahron, Hadariah
UNSPECIFIED
Kassim, Karimah
UNSPECIFIED
Muhamad, Mohd Asrul Hafiz
UNSPECIFIED
Sayed Mohamad, Syed Nazmi
UNSPECIFIED
Subjects: Q Science > QD Chemistry > Organic chemistry > Schiff bases
Q Science > QD Chemistry > Fluoropolymers
Q Science > QD Chemistry > Metal complexes. Layered double hydroxides
Divisions: Universiti Teknologi MARA, Shah Alam > Research Management Centre (RMC)
Journal or Publication Title: Scientific Research Journal
UiTM Journal Collections: UiTM Journal > Scientific Research Journal (SRJ)
ISSN: 1675-7009
Volume: 7
Number: 2
Page Range: pp. 67-90
Keywords: Metal complexes, S-2-4dichlorobenzyldithiocarbazate, 5-fluoroisatin, Schiff base, Biological activity
Date: 2010
URI: https://ir.uitm.edu.my/id/eprint/12939
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